Indoxyl sulfate inhibits muscle cell differentiation via Myf6/MRF4 and MYH2 downregulation.

Stanislas Bataille,Nathalie McKay,Laetitia Koppe, Alice Beau,Bérengère Benoit,Marc Bartoli,Nathalie Da Silva,Stéphane Poitevin,Julien Aniort,Rania Chermiti,Stéphane Burtey,Laetitia Dou

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association（2023）

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摘要

In conclusion, IS inhibits Myf6/MRF4 and MYH2 expression during differentiation of muscle cells, which could lead to a defect in myotube structure. Through these new mechanisms, IS could participate in muscle atrophy observed in chronic kidney disease.

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关键词

chronic kidney disease, indoxyl sulfate, myogenesis, uremic toxin

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