Low Susceptibility of Pigs against Experimental Infection with HPAI Virus H5N1 Clade 2.3.4.4b.

Annika Graaf, Ronja Piesche,Julia Sehl-Ewert,Christian Grund,Anne Pohlmann,Martin Beer,Timm Harder

Emerging infectious diseases（2023）

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摘要

We found that nasal and alimentary experimental exposure of pigs to highly pathogenic avian influenza virus H5N1 clade 2.3.4.4b was associated with marginal viral replication, without inducing any clinical manifestation or pathological changes. Only 1 of 8 pigs seroconverted, pointing to high resistance of pigs to clade 2.3.4.4b infection.

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hpai virus h5n1 clade,pigs,experimental infection

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