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Improved Pharmacokinetics of HIV-neutralizing VRC01-class Antibodies Achieved by Reduction of Net Positive Charge on Variable Domain

Young D. Kwon,Amarendra Pegu,Eun Sung Yang,Baoshan Zhang,Michael F. Bender,Mangaiarkarasi Asokan,Qingbo Liu,Krisha McKee,Bob C. Lin,Tracy Liu,Mark K. Louder,Reda Rawi,Mateo Reveiz,Andrew J. Schaub,Chen-Hsiang Shen,Nicole A. Doria-Rose,Paolo Lusso,John R. Mascola,Peter D. Kwong

MABS（2023）

Cited 4|Views63
Key words
Antibody-mediated prevention,net positive charge reduction,pharmacokinetics,serum half-life,surface charge,variable region,VRC01-class antibody
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