Histotripsy induces apoptosis and reduces hypoxia in a neuroblastoma xenograft model.

Isabella Iwanicki,Lydia L Wu,Fernando Flores-Guzman, Rachael Sundland,Paula Viza-Gomes,Rachel Nordgren,Connor S Centner,Jessica J Kandel,Mark A Applebaum,Kenneth B Bader,Sonia L Hernandez

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group（2023）

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摘要

In addition to ablative effects, histotripsy was found to drive tumor apoptosis through intrinsic pathways, altering blood vessel architecture, and reducing hypoxia.

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关键词

Histotripsy, neuroblastoma, hypoxia, VEGF, PDGFB, apoptosis

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