Metabolic rewiring controlled by c-Fos governs cartilage integrity in osteoarthritis.

Kazuhiko Matsuoka,Latifa Bakiri,Martin Bilban,Stefan Toegel,Arvand Haschemi,Hao Yuan,Maria Kasper,Reinhard Windhager,Erwin F Wagner

Annals of the rheumatic diseases（2023）

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摘要

c-Fos modulates cellular bioenergetics in chondrocytes by balancing pyruvate flux between anaerobic glycolysis and the tricarboxylic acid cycle in response to OA signals. We identify a novel metabolic adaptation of chondrocytes controlled by c-Fos-containing AP-1 dimers that could be therapeutically relevant.

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关键词

Osteoarthritis, Chondrocytes, Arthritis, Experimental

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