New hormone receptor-positive breast cancer mouse cell line mimicking the immune microenvironment of anti-PD-1 resistant mammary carcinoma.

Maria Perez-Lanzon,Vincent Carbonnier, Pierre Cordier,Fatima Domenica Elisa De Palma,Adriana Petrazzuolo,Christophe Klein,Floriane Arbaretaz,Khady Mangane,Gautier Stoll,Isabelle Martins, Helene Fohrer Ting,Juliette Paillet,Sophie Mouillet-Richard,Delphine Le Corre, Wenjjin Xiao,Marine Sroussi,Chantal Desdouets,Pierre Laurent-Puig,Jonathan Pol,Carlos Lopez-Otin,Maria Chiara Maiuri,Guido Kroemer

Journal for immunotherapy of cancer（2023）

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摘要

B6BC is the first transplantable HR BC cell line derived from C57BL/6 mice and B6BC-derived tumors recapitulate the complex tumor microenvironment of locally advanced HR BC naturally resistant to PD-1 immunotherapy.

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关键词

breast cancer,immune microenvironment,hormone,receptor-positive

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