A serologically assessed neo-epitope biomarker of cellular fibronectin degradation is related to pulmonary fibrosis.

Annika Hummersgaard Hansen, Helene Wallem Breisnes,Thomas Skovhus Prior,Ole Hilberg,Daniel Guldager Kring Rasmussen,Federica Genovese,Marie Vestergaard Lukassen,Birte Svensson,Lasse Løcke Langholm,Tina Manon-Jensen,Morten Asser Karsdal,Diana Julie Leeming,Elisabeth Bendstrup,Jannie Marie Bülow Sand

Clinical biochemistry（2023）

引用 0|浏览3

暂无评分

摘要

We developed the neo-epitope specific FN-EDB assay, a competitive ELISA, as a tool for serological assessment of MMP-8 mediated degradation of EDB in cellular FN. This study indicates that degradation of EDB in cellular FN is elevated in IPF and warrants further investigation.

查看译文

关键词

AGC,BMI,CV%,DLCO%,ECM,EDA,EDB,ELISA,FN,FVC%,HRP,IPF,IQR,LLOD,LLOQ,MS,MMPs,mAb,MRD,SD,MS2,FN I,FN II,FN III,ULOQ,6MWD

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要