Unraveling Dexamethasone-Induced Neurobehavioral and Sleep Problems in Children With ALL: Which Determinants Are Important?

Annelienke M van Hulst,Martha A Grootenhuis,Emma J Verwaaijen,Raphaële R L van Litsenburg,Letao Li,Bertrand D van Zelst,Linda Broer,Saskia M F Pluijm,Rob Pieters,Marta Fiocco,Erica L T van den Akker,Marry M van den Heuvel-Eibrink

JCO precision oncology（2023）

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摘要

We identified parenting stress, and not dexamethasone pharmacokinetics, genetic variation, patient/parent demographics, or disease/treatment characteristics, as a significant determinant for parent-reported dexamethasone-induced neurobehavioral and sleep problems. Parenting stress may be a modifiable target to reduce these problems.

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