Onsite Nonpotable Water Systems Pathogen Treatment Targets: A Comparison of Infection and Disability-Adjusted Life Years (DALYs) Risk Benchmark Approaches.

Pathogen log reduction targets for onsite nonpotable water systems were calculated using both annual infection (LRT) and disability-adjusted life year (LRT) benchmarks. The DALY is a measure of the health burden of a disease, accounting for both the severity and duration of illness. Results were evaluated to identify if treatment requirements change when accounting for the likelihood, duration, and severity of illness in addition to the likelihood of infection. The benchmarks of 10 infections per person per year (ppy) and 10 DALYs ppy were adopted along with multilevel dose-response models for and , which characterize the probability of illness given infection (Pill|inf) as dose-dependent using challenge or outbreak data. We found differences between treatment requirements, LRT - LRT, for some pathogens, driven by the likelihood of illness, rather than the severity of illness. For pathogens with dose-independent Pill|inf characterizations, such as spp., , and , the difference, LRT - LRT, was identical across reuse scenarios (更多