Inhibition of VEGFR2 and EGFR signaling cooperatively suppresses the proliferation of oral squamous cell carcinoma.

Maho Onda,Akinobu Ota,Kunihiro Ito,Takayuki Ono,Sivasundaram Karnan,Mikako Kato,Sayuri Kondo,Akifumi Furuhashi,Tomio Hayashi,Yoshitaka Hosokawa,Yoshiaki Kazaoka

Cancer medicine（2023）

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摘要

VEGFR-mediated signaling would be an alternative signaling pathway for the survival of OSCC cells under the disruption of EGFR signaling. These results highlight the clinical application of VEGFR inhibitors in the development of multi-molecular-targeted therapeutics against OSCC.

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关键词

drug sensitivity, EGFR, genome editing, OSCC, VEGFR

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