Combined SEPT9 and BMP3 methylation in plasma for colorectal cancer early detection and screening in a Brazilian population.

Adhara Brandão Lima,Mariana Bisarro Dos Reis,Marcus Matsushita,Monise Tadin Dos Reis,Marco Antônio de Oliveira,Rui Manuel Reis,Denise Peixoto Guimarães

Cancer medicine（2023）

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摘要

The present study suggests that a combination of SEPT9 and BMP3 plasma methylation, along with age over 60 years, showed the highest performance in detecting CRC in a Brazilian population. These noninvasive biomarkers can potentially serve as useful tools for CRC screening programs.

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关键词

cell-free DNA, colorectal cancer, digital PCR, DNA methylation, liquid biopsy

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