Cetuximab enhances radiosensitivity of esophageal squamous cell carcinoma cells by G2/M cycle arrest and DNA repair delay through inhibiting p-EGFR and p-ERK.

Guifang Zhao,Liwen Feng,Ting Ye,Yanshen Liu,Li Fan,Chengzhi Ye,Jing Chen

Thoracic cancer（2023）

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摘要

These results indicate the potential for use of cetuximab as an effective radiosensitizer in ESCC. Cetuximab promotes G2/M cycle arrest and reduces DSB repair, as well as inhibiting EGFR and downstream ERK pathways in ESCC.

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关键词

cetuximab,squamous cell carcinoma,radiosensitivity

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