Emergence of resistance-associated variants during sofosbuvir treatment in chronically infected hepatitis E patients.

André Gömer,Mara Klöhn,Michelle Jagst,Maximilian Nocke,Sven Pischke,Thomas Horvatits,Julian Schulze Zur Wiesch,Tobias Müller,Svenja Hardtke,Markus Cornberg,Heiner Wedemeyer,Patrick Behrendt,Eike Steinmann,Daniel Todt

Hepatology (Baltimore, Md.)（2023）

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摘要

In conclusion, viral population dynamics played a critical role during antiviral treatment. High population diversity during sofosbuvir treatment led to the selection of variants (especially A1343V) with lower sensitivity to the drug, uncovering a novel mechanism of resistance-associated variants during sofosbuvir treatment.

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