A hepatitis B virus-derived peptide combined with HBsAg exerts an anti-HBV effect in an HBV transgenic mouse model as a therapeutic vaccine.

Yu-Min Choi,Dong Hyun Kim,Junghwa Jang,Bum-Joon Kim

Frontiers in immunology（2023）

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摘要

Our data indicated that vaccination with Poly6 in combination with HBsAg exerts an anti-HBV effect in HBV transgenic mice, which is mainly mediated by HBV-specific CMI and humoral immune responses via IFN-I-dependent DC activation, suggesting the feasibility of Poly6 as an adjuvant for an HBV therapeutic vaccine.

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hepatitis B virus (HBV), therapeutic vaccination, adjuvant, type 1 interferon (IFN-I), (HBV)-derived peptide, Poly6, DC maturation, cell mediated immune (CMI) response

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