CD155 blockade enhances allogeneic natural killer cell-mediated antitumor response against osteosarcoma.

Monica M Cho,Longzhen Song,Aicha E Quamine,Fernanda Szewc,Lei Shi,Amy K Erbe,Jonathan D Ebben,David P Turicek,Jillian M Kline,Emily O Lafeber,Madison F Phillips,Amanda S Ceas,Paul M Sondel,Christian M Capitini

bioRxiv : the preprint server for biology（2023）

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摘要

These results demonstrate efficacy of allogeneic NK cells combined with CD155 blockade to mount an antitumor response against CD155-expressing OS. Translation of combination adoptive NK cell and CD155 axis modulation offers a platform for alloBMT treatment approaches for pediatric patients with relapsed and refractory solid tumors.

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