Clinical and metabolomic characterization of Brivanib-Induced hypertension in metastatic colorectal cancer.

Jodi I Rattner,Karen A Kopciuk,Hans J Vogel,Patricia A Tang,Jeremy D Shapiro,Dongsheng Tu,Derek J Jonker,Lillian L Siu,Chris J O'Callaghan,Oliver F Bathe

Cancer medicine（2023）

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摘要

TKI-induced hypertension was not associated with clinical benefit in metastatic CRC. We have identified changes in the metabolome that are associated with the development of worsening brivanib-induced hypertension that may be useful in future efforts of characterizing this toxicity.

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关键词

metastatic colorectal cancer,colorectal cancer,metabolomic characterization,hypertension

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