YAP/STAT3 inhibited CD8 + T cells activity in the breast cancer immune microenvironment by inducing M2 polarization of tumor-associated macrophages.

Chen Wang,Ningning Shen, Qingling Guo,Xiaohua Tan,Shaozhong He

Cancer medicine（2023）

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摘要

In conclusion, this study suggested inhibition of YAP/STAT3 reversed M2 polarization of TAMs and suppressed CD8 T-cell activity in the BC immune microenvironment. These findings open up new avenues for the development of innovative therapies in the treatment of BC.

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关键词

immune microenvironment,macrophages,breast cancer,cells

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