A multifactorial analysis of FAP to regulate gastrointestinal cancers progression.

Jialing Cai,Depeng Yang,Handi Sun,Lixing Xiao,Fang Han,Mengmeng Zhang, Lu Zhou,Meiyi Jiang,Qinghua Jiang,Yu Li,Huan Nie

Frontiers in immunology（2023）

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摘要

In summary, we employed bioinformatic tools and experiments to perform a comprehensive analysis about FAP. Up-regulation of FAP in gastrointestinal cancers was primarily expressed in fibroblasts and contributes to tumor cells motility, macrophages infiltration and M2 polarization, revealing the multifactorial role of FAP in gastrointestinal cancers progression.

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关键词

FAP, fibroblast, gastrointestinal cancers, immunology, macrophage polarization

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