Targeting complement C5a to improve radiotherapy sensitivity in non-small cell lung cancer.

Meng Yuan,Chenlin Wang,Yanan Wu,Lili Qiao,Guodong Deng,Ning Liang,Fangjie Chen,Li Liu,Yanfei Chen,Yunxin Yang,Hang Wang, Tong Liu,Xiaofan Yang, Yingying Zhang,Yajuan Lv,Rafal Suwinski,Pingping Hu,Yan Zhang,Jiandong Zhang

Translational lung cancer research（2023）

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摘要

RT promotes the release of C5a from tumor cells and leads to up-regulation of C5aR1 expression via the AKT/NF-κB pathway. Inhibition of the combination of complement C5a and C5aR could improve RT sensitivity. Our work provides evidence that the combination of RT and C5aR blockade opens a new window of opportunity to promote anti-tumor therapeutic effects in lung cancer.

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关键词

complement c5a,radiotherapy sensitivity,cancer,non-small

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