A Rapid Self-pumping Organohydrogel Dressing with Hydrophilic Fractal Microchannels to Promote Burn Wound Healing.

Burn wounds pose great challenges for conventional dressings because massive exudates oversecreted from swollen tissues and blisters seriously delay wound healing. Herein, we report a self-pumping organohydrogel dressing with hydrophilic fractal microchannels that can rapidly drain excessive exudates with ca. 30 times enhancement in efficiency compared with the pure hydrogel, and effectively promote burn wound healing. We propose a creaming-assistant emulsion interfacial polymerization approach to create the hydrophilic fractal hydrogel microchannels in the self-pumping organohydrogel through a dynamic floating-colliding-coalescing process of organogel precursor droplets. In a murine burn wound model, the rapid self-pumping organohydrogel dressings can markedly reduce dermal cavity by ca. 42.5%, accelerate blood vessel regeneration by ca. 6.6 times, and hair follicle regeneration by ca. 13.5 times, compared with the commercial dressing (Tegaderm ). This study paves an avenue for designing high-performance functional burn wound dressings. This article is protected by copyright. All rights reserved.