Novel Mechanisms Guide Innovative Molecular-Based Therapeutic Strategies for Fuchs Endothelial Corneal Dystrophy.

Matilda F Chan,Peipei Pan,Finn D Wolfreys

Cornea（2023）

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摘要

Major advances in genomics have dramatically increased our understanding of Fuchs endothelial corneal dystrophy (FECD) and identified diverse genetic causes and associations. Biomarkers derived from these studies have the potential to inform both clinical treatment and yield novel therapeutics for this corneal dystrophy.

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关键词

Fuchs endothelial corneal dystrophy, biomarkers, endothelial-mesenchymal transition (EndMT), genetics, epigenetics, protein misfolding

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