Raptinal ameliorates 1,2-dimethylhydrazine-induced colon cancer through p53/Bcl2/Bax/caspase-3-mediated apoptotic events in vitro and in vivo .

Yongting Lan,Yang Yang,Abhijit Das, Barshana Bhattacharya,Souvik Roy

Indian journal of pharmacology（2023）

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摘要

These findings indicate the raptinal effectively reduces colon cancer by inducing apoptosis through p53/Bcl2/Bax/caspase-3 pathway and suppressing IL-6, TNF-mediated chronic inflammation in the colon cancer microenvironment.

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关键词

colon cancer,raptinal ameliorates,p53/bcl2/bax/caspase-3-mediated,apoptotic events,dimethylhydrazine-induced

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