ABCA1 transporter promotes the motility of human melanoma cells by modulating their plasma membrane organization.

Ambroise Wu,Ewa Mazurkiewicz,Piotr Donizy,Krzysztof Kotowski,Małgorzata Pieniazek,Antonina J Mazur,Aleksander Czogalla,Tomasz Trombik

Biological research（2023）

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摘要

Human melanoma cells reorganize their plasma membrane cholesterol content and organization via ABCA1 activity to promote motility processes and aggressiveness potential. Therefore, ABCA1 may contribute to tumor progression and poor prognosis, suggesting ABCA1 to be a potential metastatic marker in melanoma.

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关键词

ABCA1, Cell motility, Cholesterol, Human melanoma, Plasma membrane

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