Relebactam restores susceptibility of resistant Pseudomonas aeruginosa and Enterobacterales and enhances imipenem activity against chromosomal AmpC-producing species: analysis of global SMART 2018-2020.

David W Hilbert,C Andrew DeRyke,Mary Motyl,Meredith Hackel,Katherine Young

BMC microbiology（2023）

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摘要

Relebactam restored imipenem susceptibility among nonsusceptible isolates of P. aeruginosa and Enterobacterales and enhanced imipenem susceptibility among susceptible isolates of P. aeruginosa and isolates from Enterobacterales species that can produce chromosomal AmpC. The reduced imipenem modal MIC values with relebactam may result in a higher probability of target attainment in patients.

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关键词

Minimum inhibitory concentration, Gram-negative bacteria, Antibacterial agents, Bacterial infections, Antibacterial susceptibility, Imipenem, Relebactam, Carbapenem

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