Reduction in Rubicon by cigarette smoke is associated with impaired phagocytosis and occurs through lysosomal degradation pathway.

Patrick F Asare,Plinio R Hurtado,Hai B Tran,Griffith B Perkins,Eugene Roscioli,Sandra Hodge

Clinical and experimental medicine（2023）

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摘要

CSE decreases Rubicon through the lysosomal degradation pathway. Rubicon degradation and/or LAP impairment may contribute to dysregulated phagocytosis perpetuated by CSE.

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关键词

LC3-associated phagocytosis (LAP), Rubicon, Phagocytosis, Autophagy, Inflammation

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