The association between dual RAAS inhibition and risk of acute kidney injury and hyperkalemia in patients with diabetic kidney disease: a systematic review and meta-analysis.

Reid Whitlock,Silvia J Leon, Hazel Manacsa,Nicole Askin,Claudio Rigatto, Samuel T Fatoba,Youssef M K Farag,Navdeep Tangri

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association（2023）

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摘要

Dual therapy with RAASi is associated with an increased risk of AKI and hyperkalemia compared to RAASi monotherapy. Conversely, dual therapy with RAAS inhibitors and non-steroidal MRAs have no additional risk of AKI but a similar risk of hyperkalemia, which is lower than dual therapy with RAAS inhibitors and steroidal MRAs.

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关键词

acute kidney injury, ACEi, ARB, diabetic kidney disease, dual RAAS inhibitors

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