Excess cerebellar granule neurons induced by the absence of p75NTR during development elicit social behavior deficits in mice.

Juan Pablo Zanin, Mansi A Pandya,Diego Espinoza, Wilma J Friedman,Michael W Shiflett

Frontiers in molecular neuroscience（2023）

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摘要

Our findings demonstrate that alterations to CGN development by loss of p75NTR alter social behavior, and contribute to the increasing evidence that the cerebellum plays a role in non-motor-related behaviors, including social behavior.

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关键词

p75NTR, granule cell precursor (GCPs), neurotrophins, cerebellum, social behavior

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