Role of Pellino-1 in Inflammation and Cardioprotection following Severe Sepsis: A Novel Mechanism in a Murine Severe Sepsis Model † .

Mahesh Thirunavukkarasu,Santosh Swaminathan,Andrew Kemerley,Seetur R Pradeep,Sue Ting Lim,Diego Accorsi,Rickesha Wilson,Jacob Campbell, Ibnalwalid Saad,Siu-Pok Yee,J Alexander Palesty,David W McFadden,Nilanjana Maulik

Cells（2023）

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摘要

Our results indicate that overexpression of Peli1 is a novel approach that not only preserved cardiac function but reduced inflammatory markers and apoptosis following severe sepsis in a murine genetic model.

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关键词

severe sepsis,inflammation,cardioprotection

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