Exploring the effect and mechanism of Haizao Yuhu decoction containing three variants of glycyrrhiza on goiter using an integrated strategy of network pharmacology and RNA sequencing.

Journal of ethnopharmacology(2023)

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摘要
This study confirmed the definite effect of the three HYDs in the treatment of goiter, and HYD-U was found to be more effective. The three HYDs inhibited angiogenesis and cell proliferation in goiter tissue by inhibiting the PI3K-Akt signaling pathway.
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关键词
Haizao Yuhu decoction, Three species of glycyrrhiza, Goiter, Network pharmacology combined with RNA-Seq, PI3K-Akt pathway
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