Physiologically-based pharmacokinetics modeling of Semaglutide in children and adolescents with healthy and obese body weights.

Thayná Rocco Machado,Thiago Honorio, Thaisa F Souza Domingos, Dailane da Silva Candido de Paula,Lucio Mendes Cabral,Carlos R Rodrigues,Bárbara A Abrahim-Vieira,Alessandra Mendonça Teles de Souza

British journal of clinical pharmacology（2023）

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摘要

Pediatric PBPK was successfully achieved using a top-down approach and drug-related parameters. The development of unprecedented PBPK models will support pediatric clinical therapy for applying aid-safe dosing regimens for the pediatric population in diabetes treatment.

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pharmacokinetic modelling,semaglutide,obese body weights

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