Specific dilation pattern in placental circulation and the NO/sGC role in preeclampsia placental vessels.
Frontiers in endocrinology(2023)
摘要
This study demonstrated that receptor-mediated endothelium-dependent dilation in placental circulation was significantly weaker than other vessels in various species. The results, showed firstly, that exogenous NO played a role in regulating the baseline tone of placental circulation sGC. Lower NO production and decreased NO/sGC could be one of the reasons for preeclampsia. The findings contribute to understanding specific features of placental circulation and provide information about preeclampsia in placental vessels.
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关键词
feto-placental circulation, placental vessel, dilation, nitric oxide, preeclampsia, soluble guanylate cyclase (sGC)
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