Lipoprotein(a) induces caspase-1 activation and IL-1 signaling in human macrophages.

Martina B Lorey,Amer Youssef,Lauri Äikäs,Matthew Borrelli,Martin Hermansson,Julia M Assini,Aapeli Kemppainen,Hanna Ruhanen,Maija Ruuth,Sampsa Matikainen,Petri T Kovanen,Reijo Käkelä,Michael B Boffa,Marlys L Koschinsky,Katariina Öörni

Frontiers in cardiovascular medicine（2023）

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摘要

Our data show that Lp(a) particles induce the expression of inflammatory genes, and Lp(a) and to a lesser extent apo(a) induce caspase-1 activation and IL-1 signaling. Major differences in the molecular profiles between Lp(a) and LDL contribute to Lp(a) being more atheroinflammatory.

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关键词

inflammation, lipoprotein(a), apolipoproteins, atherosclerotic cardiovascular disease, atherosclerosis, caspase-1, interleukin-1 family

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