Loss or gain of function? Effects of ion channel mutations on neuronal firing depend on the neuron type.

Nils A Koch,Lukas Sonnenberg,Ulrike B S Hedrich,Stephan Lauxmann,Jan Benda

Frontiers in neurology（2023）

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摘要

Consequently, neuron-type specific effects are vital to a full understanding of the effects of channelopathies on neuronal excitability and are an important step toward improving the efficacy and precision of personalized medicine approaches.

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关键词

channelopathies, epilepsy, ataxia, potassium currents, neuronal simulation, conductance-based models, neuronal heterogeneity

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