Shexiang Tongxin Dropping Pill alleviates M1 macrophage polarization-induced inflammation and endothelial dysfunction to reduce coronary microvascular dysfunction via the dectin-1/Syk/IRF5 pathway.

Lingwen Cui,Yizhou Liu,Yueyao Hu,Jianteng Dong,Qiong Deng,Boyang Jiao,Ying Sun,Yan Wu,Tianhua Liu,Wei Wang,Chun Li

Journal of ethnopharmacology（2023）

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摘要

STDP can alleviate M1 macrophage polarization-induced inflammation and endothelial dysfunction against CMD via the Dectin-1/Syk/IRF5 pathway. Dectin-1-associated M1 macrophage polarization might be developed as a novel target for ameliorating CMD.

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关键词

Coronary microvascular dysfunction, Shexiang Tongxin Dropping Pill (STDP), Endothelial dysfunction, Sterile inflammation, M1 macrophage polarization, Dectin-1, Syk, IRF5 pathway

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