Analysis of core mutation and TET2/ASXL1 mutations DNA methylation profile in myelodysplastic syndrome.

Yue Feng,Haiping Liang, Meining Han,Xingchun Luo, Yu Zhu,Bei Liu

Hematology (Amsterdam, Netherlands)（2023）

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摘要

Our results illustrate the interrelationships between genetic mutations and clinical phenotypes and disease outcomes, with substantial potential for clinical application. Differentially methylated hub genes might represent potential biomarkers and provide novel insights and possible targets for MDS with double TET2/ASXL1 mutations.

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关键词

Myelodysplastic syndrome, gene mutation, DNA methylation, prognosis, survival analysis, bioinformatics, GO enrichment analysis, KEGG pathway analysis

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