High-fat diet and palmitic acid amplify airway type 2 inflammation.

Kris Genelyn Dimasuay,Bruce Berg,Niccolette Schaunaman,Fernando Holguin,Daniel Winnica,Hong Wei Chu

Frontiers in allergy（2023）

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摘要

Our results demonstrated the exaggerating effect of obesity or PA on airway type 2 inflammation. Up-regulation of soluble DPP4 by IL-13 and/or PA may serve as a mechanism to prevent excessive type 2 inflammation. Soluble DPP4 may have the therapeutic potential in asthma patients with obesity who have an endotype with mixed airway eosinophilic and neutrophilic inflammation.

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airway,inflammation,diet,high-fat

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