Identification and validation of subclusters of papillary thyroid carcinoma based on Human Phenotype Ontology.

Zixue Xuan,Xiaoping Hu,Tong Xu,Yujia Liu,Zongfu Pan, Minhua Ge,Juan J Díez,Ping Huang,Jiajie Xu,Zhuo Tan

Gland surgery（2023）

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摘要

We first identified subclusters in PTC based on HPO and found that patients with distinct subclusters have different prognoses. We then identified and validated the characteristic genes in the 4 subclusters. These findings are expected to serve as a crucial reference that will improve our understanding of PTC heterogeneity and the use of novel targets.

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关键词

Papillary thyroid carcinoma ( PTC), Human Phenotype Ontology (HPO), subcluster, single-cell RNA-sequencing (scRNA-seq), prognosis

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