Editorial: The management of hematologic malignancies in lower-income countries.

the challenges of managing hematologic malignancies in LMICs.In their article, Salama et al. from Egypt discuss the challenges in managing mixed-phenotype 19 acute leukemia (MPAL) in LMICs. MPAL is a relatively rarer subtype of acute leukemias, and 20 there is limited data, especially on children from LMICs (5,6). With little data available on this 21 rare subtype of acute leukemias, particularly in LMIC children, the authors report on a series 22 of 42 children treated for MPAL, achieving a 5-year event-free survival (EFS) of 56% and overall 23 survival (OS) of 61%. These results are comparable to data from two pediatric MPAL series in 24 India, highlighting the challenges in managing high-risk pediatric leukemias in resource-25 limited settings (5,6). In one of the largest reports of pediatric MPALs from LMICs, the authors 26 highlight the difficulties of treating high-risk pediatric leukemia in resource-limited settings. The findings suggest a 5-year EFS rate of 49% (56% in CR1 and 32% in CR2), and an OS rate of 56%. Although current practice in pediatric (Ph+) ALL does not typically involve offering CR1