Dynamics and survival associations of T cell receptor clusters in patients with pleural mesothelioma treated with immunotherapy.

Aakash P Desai,Farhad Kosari,Maria Disselhorst,Jun Yin,Alireza Agahi,Tobias Peikert,Julia Udell,Sarah H Johnson,James Smadbeck,Stephen Murphy,Giannoula Karagouga,Alexa McCune,Janet Schaefer-Klein,Mitesh J Borad,John Cheville,George Vasmatzis,Paul Baas,Aaron Mansfield

Journal for immunotherapy of cancer（2023）

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摘要

We identified two unique TCR clusters that were associated with survival on treatment with ICI in patients with pleural mesothelioma. These clusters may enable approaches for antigen discovery and inform future targets for design of adoptive T cell therapies.

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pleural mesothelioma,immunotherapy

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