Control of enhancer and promoter activation in the type I interferon response by the histone demethylase Kdm4d/JMJD2d.

Rohit Chandwani,Terry C Fang,Scott Dewell,Alexander Tarakhovsky

Frontiers in immunology（2023）

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摘要

Taken together, our data reveal JMJD2d as a chromatin modifier that connects enhancer transcription with promoter demethylation to modulate transcriptional responses.

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关键词

JMJD2D, KDM4D, type I interferon response, innate immunity, enhancer chromatin, IFN-beta, eRNA, histone demethylation

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