Clinical metagenomic sequencing of plasma microbial Cell-free DNA for febrile neutropenia in acute leukemia patients.

Sizhou Feng,Guanhua Rao,Xudong Wei,Rong Fu,Ming Hou,Yongping Song,Chunhui Xu,Peng Han,Benfa Gong, Xin Chen,Yihao Wang,Xiaoyuan Dong, Zhi Jiang,Jianxiang Wang

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases（2023）

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摘要

Our results indicate that mNGS of plasma mcfDNA increased the detection of clinically-significant pathogens and enabled early optimization of antimicrobial therapy in AL patients with FN.

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