Disparities in parental distress in a multicenter clinical trial for pediatric acute lymphoblastic leukemia.

Despite uniform clinical trial treatment of their children at well-resourced pediatric centers, HMH-exposed parents-compared to unexposed parents-experienced significantly increased odds of severe psychological distress at the time of their child's leukemia diagnosis which worsened 6-months into therapy. These data identify a high-risk parental population who may benefit from early psychosocial and HMH-targeted interventions to mitigate disparities in well-being.