Preserved blood-brain barrier and neurovascular coupling in female 5xFAD model of Alzheimer's disease.

Our findings provide direct evidence of preserved microvascular function in the 5xFAD mice and highlight the critical dependence of the experimental outcomes on the choice of preclinical models of AD. We propose that the presence of parenchymal A does not warrant BBB and NVC dysfunction and that the generalized view that microvascular impairment is inherent to A aggregation may need to be revised.