CD47 Activation by Thrombospondin-1 in Lymphatic Endothelial Cells Suppresses Lymphangiogenesis and Promotes Atherosclerosis.

Bhupesh Singla, Ravi Varma Aithbathula,Naveed Pervaiz,Ishita Kathuria, Mallory Swanson,Frederick Adams Ekuban,WonMo Ahn,Frank Park, Maxwell Gyamfi,Mary Cherian-Shaw,Udai P Singh,Santosh Kumar

Arteriosclerosis, thrombosis, and vascular biology（2023）

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摘要

These findings demonstrate that TSP1 inhibits lymphangiogenesis via activation of CD47 in LEC, and loss of LEC attenuates atherosclerotic lesion formation. Collectively, these results identify LEC CD47 as a potential therapeutic target in atherosclerosis.

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关键词

aorta, atherosclerosis, endothelial cells, fasting, lymphangiogenesis

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