Single CAR-T cell treatment controls disseminated ovarian cancer in a syngeneic mouse model.

Diana Rose E Ranoa,Preeti Sharma, Claire P Schane, Amber N Lewis, Edward Valdez,Venkata V V R Marada, Marlies V Hager, Will Montgomery,Steven P Wolf,Karin Schreiber,Hans Schreiber, Keith Bailey,Timothy M Fan,Paul J Hergenrother,Edward J Roy,David M Kranz

Journal for immunotherapy of cancer（2023）

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摘要

The findings support the development of affinity-optimized CAR-T cells as a potential treatment for established ovarian cancer, with the most effective CARs mediating a distinct pattern of inflammatory cytokine release in vitro. Importantly, the most potent Tn-dependent CAR-T cells showed no evidence of toxicity in tumor-bearing mice in a syngeneic, immunocompetent system.

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关键词

Receptors, Chimeric Antigen, T-Lymphocytes, Immunotherapy, Antigens, Tumor-Associated, Carbohydrate, Cell Engineering

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