Cell surface marker-based capture of neoantigen-reactive CD8 + T-cell receptors from metastatic tumor digests.

Praveen D Chatani,Frank J Lowery,Neilesh B Parikh,Kyle J Hitscherich,Rami Yossef,Victoria Hill,Jared J Gartner,Biman Paria,Maria Florentin,Satyajit Ray,Alakesh Bera, Maria Parkhust,Paul Robbins,Sri Krishna,Steven A Rosenberg

Journal for immunotherapy of cancer（2023）

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摘要

While direct usage of in vitro-expanded CD8 TIL as a source for cellular therapy might be precluded by profound TIL dysfunction, isolating TIL represents a streamlined effective approach to rapidly identify neoantigen-reactive TCRs to design engineered cellular immunotherapies against cancer.

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关键词

CD8-Positive T-Lymphocytes, Cell Engineering, Immunity, Cellular, Immunotherapy, Lymphocytes, Tumor-Infiltrating

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