The antidepressant-like effects of escitalopram in mice require salt-inducible kinase 1 and CREB-regulated transcription co-activator 1 in the paraventricular nucleus of the hypothalamus.

Tian-Shun Shi,Wei-Yu Li,Yan-Mei Chen,Jie Huang,Wei Guan,Da-Wei Xu,Bo Jiang

Journal of affective disorders（2023）

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摘要

In summary, regulating the SIK1-CRTC1 system in the PVN participates in the antidepressant mechanism of escitalopram, which extends the knowledge of the pharmacological actions of escitalopram.

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关键词

Chronic social defeat stress,Chronic unpredictable mild stress,CREB-regulated transcription co-activator 1,Depression,Escitalopram,Salt-inducible kinase 1

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