Bone health and prevalent fractures in women with polycystic ovary syndrome: a meta-analysis and endocrine-context pathophysiology review.

Jerilynn C Prior,Sonia Shirin,Azita Goshtasebi

Expert review of endocrinology & metabolism（2023）

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摘要

Is fracture risk altered by PCOS? Our meta-analysis showed a 25% increased risk of prevalent fracture in PCOS versus controls; this did not reach statistical significance. Future prospective research needs to collect and evaluate ovulation characteristics, progesterone exposure, and adolescent CHC use, in addition to the complex variables that may influence risks for prevalent or incident fragility fractures and/or for cortical and cancellous aBMD values in PCOS.

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关键词

Polycystic ovary Syndrome, areal bone mineral density, volumetric bone mineral density, androgen excess, ovulatory disturbances, combined hormonal contraceptives, prevalent fractures, body mass index

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