Overexpression of heat-shock protein 47 impacts survival of patients with oral squamous cell carcinoma.

Bruno Cesar da Costa,Mauricio Rocha Dourado,Everton Freitas de Moraes, Luana Marí Panini,Amr Elseragy,Fábio Haach Téo,Gustavo Narvaes Guimarães,Renato Assis Machado,Maija Risteli,Clarissa Araujo Gurgel Rocha,Lívia Máris Ribeiro Paranaíba,Wilfredo Alejandro González-Arriagada,Sabrina Daniela da Silva,Ana Lucia Carrinho Ayroza Rangel,Marcelo Rocha Marques,Tuula Salo,Ricardo D Coletta

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology（2023）

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摘要

Our results show a significant prognostic impact of HSP47 overexpression in OSCC and reveal that HSP47 inhibition impairs the proliferation, migration, and invasion of OSCC cells. HSP47 may represent a potential therapeutic target for OSCC.

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heat‐shock heat‐shock,carcinoma,protein,impacts survival

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