Serotonin reuptake transporter deficiency promotes liver steatosis and impairs intestinal barrier function in obese mice fed a Western-style diet.

Louisa Filipe Rosa, Eva Haasis, Annkathrin Knauss,Daria Guseva,Stephan C Bischoff

Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society（2023）

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摘要

Our data demonstrate that SERT knockout causes weight gain, liver steatosis, and leaky gut, especially in mice fed a WSD. Therefore, SERT induction could be a novel therapeutic approach to improve metabolic diseases associated with intestinal barrier dysfunction.

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关键词

obese mice,serotonin,liver steatosis,intestinal barrier function

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